Urolithin A is the main metabolite of ellagitannin-rich foods, such as pomegranates, black raspberries, raspberries, strawberries, walnuts and almonds. These polyphenol components are not absorbed intact into the bloodstream, but are hydrolyzed to ellagic acid in the gut, which is then metabolized by the gut microflora to form urolithin A and B. Research indicates that the ability to synthesize urolithins declines with age and depends on the gut microflora, and there is a small percentage of the population that is unable to perform this conversion at all. Research indicates that urolithin A supports autophagy, the natural process of cellular renewal/replacement in which the body degrades and recycles cellular components, as well as mitophagy, the clearance and recycling of older and dysfunctional mitochondria. Mitochondria are the “powerhouses of the cell” and their function is fundamental to health. Supporting autophagy reduces oxidative stress and supports healthy cytokine balance within the cells .
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